SDRF-Proteomics

immunopeptidomics

v1.0.0 experiment

SDRF template for immunopeptidomics experiments (MHC-bound peptide identification). Works with any organism - combine with appropriate sample template (human for HLA typing, vertebrates for H-2/MHC typing in mouse, etc.).

Key Guidance

The immunopeptidomics template captures MHC-bound peptidome analysis metadata for

immunology, vaccine design, and neoantigen discovery studies.

Key guidance:

  • characteristics[mhc protein complex]: Required. Specify the MHC class targeted

(class I, class II, non-classical, mutant). Determines the expected peptide length

distribution (class I: 8-12aa, class II: 12-25aa).

  • characteristics[mhc typing]: Use IPD-IMGT/HLA notation for human (HLA-A*02:01),

H-2 notation for mouse (H-2Kb, H-2Db). Supports 2-4 field resolution and multi-allele

semicolon-separated format (HLA-A*02:01;HLA-B*07:02;HLA-C*07:02).

  • characteristics[mhc typing method]: How alleles were determined (NGS-based typing,

sequence-based typing, predicted from RNA-seq, inferred from mass spectrometry,

inbred strain known genotype).

  • characteristics[antibody enrichment]: The antibody clone used for immunoprecipitation.

Common clones: W6/32 (pan-class I), BB7.2 (HLA-A*02), Tu39 (pan-class II).

  • characteristics[immunopeptidome enrichment method]: The IP method used (immunoaffinity

purification, mild acid elution, detergent lysis).

Combine with human template for HLA typing or vertebrates for mouse H-2 typing.

Inheritance

base sample-metadata ms-proteomics immunopeptidomics

Columns

5 own + 59 inherited = 64 total · click a row for details
Column Requirement Source Description
characteristics[mhc protein complex] required immunopeptidomics MHC protein complex targeted for immunopeptidome enrichment (GO:0042611)
MHC protein complex targeted for immunopeptidome enrichment (GO:0042611)
values — values: MHC class I protein complex, MHC class II protein complex, non-classical MHC protein complex, mutant MHC protein complex, MHC protein complex with serotype
MHC protein complex type should be specified (MRO terms under GO:0042611)
characteristics[immunopeptidome enrichment method] required immunopeptidomics Method used to enrich MHC-bound peptides
Method used to enrich MHC-bound peptides
values — values: immunoaffinity purification, immunoaffinity purification (iodoacetamide), mild acid elution, detergent lysis
Enrichment method for immunopeptidome
characteristics[mhc typing] recommended immunopeptidomics MHC alleles expressed by the sample (PRIDE:0000893) following IPD-MHC nomenclature (https://www.e...
MHC alleles expressed by the sample (PRIDE:0000893) following IPD-MHC nomenclature (https://www.ebi.ac.uk/ipd/mhc/). Use IPD-IMGT/HLA notation for human (HLA-A*02:01), H-2 notation for mouse (H-2Kb, H-2Db), or appropriate IPD-MHC notation for other species. Multiple alleles can be separated by semicolons.
allows N/A allows not available
pattern — pattern: ^.+$
MHC allele notation (HLA for human, H-2 for mouse). Supports multi-allele (semicolon-separated), 2-4 field resolution.
HLA-A*02:01, HLA-B*07:02, HLA-A*02:01;HLA-B*07:02;HLA-C*07:02, HLA-A*02:01:01, HLA-A*02:01:01:01, H-2Kb, H-2Db, H-2IAb
characteristics[antibody enrichment] recommended immunopeptidomics Antibody clone used for MHC immunoprecipitation
Antibody clone used for MHC immunoprecipitation
allows N/A allows not available
pattern — pattern: ^.+$
Antibody clone name
W6/32, BB7.2
characteristics[mhc typing method] optional immunopeptidomics MHC typing method used (PRIDE:0000894). Values mapped to NCIT where available: NGS-based typing (...
MHC typing method used (PRIDE:0000894). Values mapped to NCIT where available: NGS-based typing (NCIT:C101293), sequence-based typing (NCIT:C130180), PCR-SSO (NCIT:C130181), PCR-SSP (NCIT:C130179), PCR-based genotyping (NCIT:C17003)
allows N/A allows not available
values — values: NGS-based typing, sequence-based typing, PCR-SSO, PCR-SSP, PCR-based genotyping, predicted from RNA-seq, …
MHC typing method used (PRIDE:0000894). Values mapped to NCIT where available: NGS-based typing (NCIT:C101293), sequence-based typing (NCIT:C130180), PCR-SSO (NCIT:C130181), PCR-SSP (NCIT:C130179), PCR-based genotyping (NCIT:C17003)

Contributors